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The altered landscapeof the human skinmicrobiome inpatients with primaryimmunodeficiencies Julia OhAlexandra F. FreemanMorgan Park2013 год

The altered landscape of the human skin microbiome in patients with primary immunodeficiencies
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Аннотация: While landmark studies have shown that microbiota activate and educate host immunity, how immune systems shape microbiomes and contribute to disease is incompletely characterized. Primary immunodeficiency (PID) patients suffer recurrent microbial infections, providing a unique opportunity to address this issue. To investigate the potential influence of host immunity on the skin microbiome, we examined skin microbiomes in patients with rare monogenic PIDs: hyper-IgE (STAT3-deficient), Wiskott-Aldrich, and dedicator of cytokinesis 8 syndromes. While specific immunologic defects differ, a shared hallmark is atopic dermatitis (AD)–like eczema. We compared bacterial and fungal skin microbiomes (41 PID, 13 AD, 49 healthy controls) at four clinically relevant sites representing the major skin microenvironments. PID skin displayed increased ecological permissiveness with altered population structures, decreased site specificity and temporal stability, and colonization with microbial species not observed in controls, including Clostridium species and Serratia marcescens . Elevated fungal diversity and increased representation of opportunistic fungi ( Candida, Aspergillus ) supported increased PID skin permissiveness, suggesting that skin may serve as a reservoir for the recurrent fungal infections observed in these patients. The overarching theme of increased ecological permissiveness in PID skin was counterbalanced by the maintenance of a phylum barrier in which colonization remained restricted to typical human-associated phyla. Clinical parameters, including markers of disease severity, were positively correlated with prevalence of Staphylococcus , Corynebacterium , and other less abundant taxa. This study examines differences in microbial colonization and community stability in PID skin and informs our understanding of host–microbiome interactions, suggesting a bidirectional dialogue between skin commensals and the host organism.
Год издания: 2013
Авторы: Julia Oh, Alexandra F. Freeman, Morgan Park, Robert Sokolic, Fabio Candotti, Steven M. Holland, Julia A. Segre, Heidi H. Kong
Издательство: Cold Spring Harbor Laboratory Press
Источник: Genome Research
Ключевые слова: Dermatology and Skin Diseases, T-cell and B-cell Immunology, Allergic Rhinitis and Sensitization
Другие ссылки: Genome Research (PDF)
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Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
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