1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Safety and efficacyof interrupteddabigatran forperi-proceduralanticoagulation incatheter ablation ofatrial fibrillation Aref A. Bin AbdulhakAbdur Rahman KhanImad M. Tleyjeh2013 год

Safety and efficacy of interrupted dabigatran for peri-procedural anticoagulation in catheter ablation of atrial fibrillation: a systematic review and meta-analysis

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: To examine the safety (defined as bleeding risk) and efficacy (defined as prevention of thromboembolic events) of interrupted dabigatran for peri-procedural anticoagulation in catheter ablation (CA) of atrial fibrillation (AF) in comparison with warfarin. Reviewers independently searched literature databases from January 2010 through April 2013 for studies comparing the safety and efficacy of dabigatran and warfarin in CA of AF and extracted pre-defined data. The Mantel–Haenszel method was used to pool data of bleeding and thromboembolism outcomes into random and fixed effect model meta-analyses, respectively. Odds ratios (ORs), and risk difference (RD) analysis when studies reported no events in either arm, were used to generate an overall effect estimate of both outcomes. Publication bias and heterogeneity were assessed by contour funnel plot and the I2 test, respectively. Nine citations, including 3036 patients (1073 dabigatran), met the inclusion criteria. There was no significant difference between interrupted dabigatran and warfarin therapy in CA of AF in occurrence of bleeding [dabigatran 58 (5.4%), warfarin 103 (5.2%); OR 0.92 (95% confidence interval (CI) 0.55–1.45); χ2 = 13.03—P = 0.11; I2 = 39%] or thromboembolism [dabigatran 5 (0.4%), warfarin 2 (0.1%); OR 2.15 (95% CI—0.58–7.98); χ2 = 2.14, P = 0.54; I2 = 0%; RD 0.00 (95% CI—0.00 to 0.01); χ2 = 3.37, P = 0.81; I2 = 0%]. Analysis of pre-defined subgroups (published articles vs. abstracts), sensitivity analyses (interrupted warfarin, USA studies, and Japanese studies) and fixed effect model analyses showed similar results. Heterogeneity was mild in the bleeding outcome analysis and zero in thromboembolism. There was no evidence of publication bias in either meta-analysis. Meta-analysis of currently available studies showed no significant difference in bleeding and thromboembolism between interrupted dabigatran and warfarin therapy in CA of AF. Dabigatran appears to be safe and effective for peri-procedural anticoagulation in CA of AF.
Год издания: 2013
Авторы: Aref A. Bin Abdulhak, Abdur Rahman Khan, Imad M. Tleyjeh, John A. Spertus, Susan U. Sanders, Kristy Steigerwalt, Musa A. Garbati, Reem A Bahmaid, Alan P. Wimmer
Издательство: Oxford University Press
Источник: EP Europace
Ключевые слова: Atrial Fibrillation Management and Outcomes, Cardiac Arrhythmias and Treatments, Cardiac electrophysiology and arrhythmias
Другие ссылки: EP Europace (PDF)
EP Europace (HTML)
PubMed (HTML)