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Immune systemresponse to stressfactors Massimo AmadoriBruno StefanonSandy Sgorlon2009 год

Immune system response to stress factors
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: This review highlights fundamental mechanisms of the stress response and important findings as to how the immune system is affected and affects, in turn, such a response. The crucial link between stress response and energy metabolism is dealt with as well. The effector mechanisms in the stress response are remarkably similar for both infectious and non–infectious stimuli, albeit differently modulated. "Psycho-sensitive stimuli/behavioural response" and "Antigenic stimuli/immune response" are indeed two subsystems of a unitary, integrated complex aimed at providing optimal conditions for the host's survival and adaptation.The interaction between the immune system and the stress/inflammation complex has led to the development of a diversified network of cytokines and chemokines in vertebrate animals. The cytokine response can be mounted in different forms and extent by the host after exposure to both infectious and non-infectious stimuli. In this conceptual framework, microbial infections are just one category of stressing agents, which modulate the cytokine response for a better performance of the innate and adaptive immune responses.The response to infectious and non–infectious stress leads to a metabolic shift that enhances energy, amino acids and micronutrients consumption. The influence of each nutrient on different aspects of immune function is not easy to define, but it is becoming clear that many nutrients have defined roles in the immune response and, accordingly, their requirements are changed to support optimal immune function. Therefore, impairment of immune functions may arise from intakes of nutrients below or above these modified ranges of requirements.
Год издания: 2009
Авторы: Massimo Amadori, Bruno Stefanon, Sandy Sgorlon, Maura Farinacci
Издательство: Taylor & Francis
Источник: Italian Journal of Animal Science
Ключевые слова: Stress Responses and Cortisol, Immune Response and Inflammation, Immune Cell Function and Interaction
Другие ссылки: Italian Journal of Animal Science (PDF)
Italian Journal of Animal Science (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)