1. Главная
  2. Ресурсы
  3. Библиотечный поиск
ClinicopathologicFeatures ofIntraductal PapillaryNeoplasm of the BileDuct According toHistologic Subtype Kwang Min KimJong Kyun LeeJae Uk Shin2011 год

Clinicopathologic Features of Intraductal Papillary Neoplasm of the Bile Duct According to Histologic Subtype
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: OBJECTIVES: Despite an increase in the reports of intraductal papillary neoplasm of the bile duct (IPN-B), the clinical characteristics and long-term prognosis of this disease are not well known compared with those of intraductal papillary mucinous neoplasms of the pancreas. The objective of our study was to compare the clinical features, radiologic findings, and clinical outcomes of IPN-B according to histologic subtype. METHODS: A retrospective analysis was performed on the medical records of 97 patients diagnosed with IPN-B by pathologic analysis of their surgical specimens between May 1995 and May 2010. We compared the clinical manifestations, radiological findings, pathologic grade, curative resection rate, recurrence, and overall survival according to four histologic subtypes: gastric (n=15), intestinal (n=46), pancreaticobiliary (n=33), and oncocytic (n=3), which were classified on the basis of hematoxylin and eosin staining and the immunohistochemical profile of mucin core proteins. RESULTS: Mucin hypersecretion was significantly more frequent in patients with gastric and intestinal types than it was in those with oncocytic and pancreaticobiliary types (P=0.014). There were no significant differences between groups regarding the presence of bile duct stones or tumor location. The frequency of invasive carcinoma in the pancreaticobiliary type was significantly higher than those in the gastric and intestinal types (72.7 vs. 26.7 and 32.6%,P<0.001 andP<0.001). When comparing the survival curves according to histologic subtype, patients with pancreaticobiliary type demonstrated significantly worse survival compared to those with gastric and intestinal types (P=0.035). CONCLUSIONS: Gastric and intestinal types of IPN-B have similar clinical characteristics compared with the pancreaticobiliary type, which has a worse prognosis.
Год издания: 2011
Авторы: Kwang Min Kim, Jong Kyun Lee, Jae Uk Shin, Kwang Hyuck Lee, Kyu Taek Lee, Ji‐Youn Sung, Kee‐Taek Jang, Jin Seok Heo, Seong‐Ho Choi, Dong Wook Choi, Jae Hoon Lim
Издательство: Lippincott Williams & Wilkins
Источник: The American Journal of Gastroenterology
Ключевые слова: Cholangiocarcinoma and Gallbladder Cancer Studies, Pancreatic and Hepatic Oncology Research, Pediatric Hepatobiliary Diseases and Treatments
Другие ссылки: The American Journal of Gastroenterology (HTML)
PubMed (HTML)