Аннотация:To understand differential time activation of nuclear factor κB (NF‐κB) and the temporal features of the downstream pro‐inflammatory cytokines’ [tumour‐necrosis‐factor‐α (TNF‐α) and IP‐10] mRNA levels in myeloid differentiation primary‐response protein 88 (MyD88) knockouts (KOs), I developed a computational model of the TLR4 pathway. The result suggests that the late phase expression of NF‐κB activity observed in MyD88 KOs is possibly due to a number of novel intermediates acting along the MyD88‐independent pathway. I also simulate that the TNF‐α levels will increase at a longer time in MyD88 KOs, not previously mentioned.
