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Complexin-I IsRequired forHigh-FidelityTransmission at theEndbulb of HeldAuditory Synapse Nicola StrenzkeSoham ChandaConny Kopp‐Scheinpflug2009 год

Complexin-I Is Required for High-Fidelity Transmission at the Endbulb of Held Auditory Synapse
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Аннотация: Complexins (CPXs I–IV) presumably act as regulators of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, but their function in the intact mammalian nervous system is not well established. Here, we explored the role of CPXs in the mouse auditory system. Hearing was impaired in CPX I knock-out mice but normal in knock-out mice for CPXs II, III, IV, and III/IV as measured by auditory brainstem responses. Complexins were not detectable in cochlear hair cells but CPX I was expressed in spiral ganglion neurons (SGNs) that give rise to the auditory nerve. Ca2+-dependent exocytosis of inner hair cells and sound encoding by SGNs were unaffected in CPX I knock-out mice. In the absence of CPX I, the resting release probability in the endbulb of Held synapses of the auditory nerve fibers with bushy cells in the cochlear nucleus was reduced. As predicted by computational modeling, bushy cells had decreased spike rates at sound onset as well as longer and more variable first spike latencies explaining the abnormal auditory brainstem responses. In addition, we found synaptic transmission to outlast the stimulus at many endbulb of Held synapses in vitro and in vivo, suggesting impaired synchronization of release to stimulus offset. Although sound encoding in the cochlea proceeds in the absence of complexins, CPX I is required for faithful processing of sound onset and offset in the cochlear nucleus.
Год издания: 2009
Авторы: Nicola Strenzke, Soham Chanda, Conny Kopp‐Scheinpflug, Darina Khimich, Kerstin Reim, Anna V. Bulankina, Andreas Neef, Fred Wolf, Nils Brose, Matthew A. Xu‐Friedman, Tobias Moser
Издательство: Society for Neuroscience
Источник: Journal of Neuroscience
Ключевые слова: Hearing, Cochlea, Tinnitus, Genetics, Neuroscience and Neuropharmacology Research, Neural dynamics and brain function
Другие ссылки: Journal of Neuroscience (PDF)
Journal of Neuroscience (HTML)
INDIGO (University of Illinois at Chicago) (PDF)
INDIGO (University of Illinois at Chicago) (HTML)
Leicester Research Archive (University of Leicester) (PDF)
Leicester Research Archive (University of Leicester) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)