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Comparison betweenTEWL and laserscanning microscopymeasurements for thein vivocharacterization ofthe human epidermalbarrier Theognosia VergouSabine SchanzerHeike Richter2011 год

Comparison between TEWL and laser scanning microscopy measurements for the in vivo characterization of the human epidermal barrier
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Аннотация: Abstract The analysis of the skin barrier properties is important in various fields of medical treatment and cosmetology. The development and improvement of topically applied substances require an objective analysis of the skin barrier characteristics. Transepidermal water loss (TEWL) measurement is the standard method to characterize epidermal barrier function. The most important disadvantage of this method though, is that it can be affected by different exogenous and endogenous factors, e.g. water content of the applied formulation and room temperature. In the present study, TEWL measurements are compared to laser scanning microscopic (LSM) measurements, concerning the use of these two methods for the non‐invasive in vivo characterization of the epidermal barrier function. The investigations were performed prior and subsequent to treatment of dry skin with a gel mixture, developed for skin treatment after radiotherapy for cancer. The present results indicate that in vivo laser scanning microscopy is an appropriate method for the characterization of the skin barrier structure without interference by external factors. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Год издания: 2011
Авторы: Theognosia Vergou, Sabine Schanzer, Heike Richter, Ragna Pels, Gisela Thiede, Alexa Patzelt, Martina C. Meinke, Wolfram Sterry, Joachim W. Fluhr, Jürgen Lademann
Издательство: Wiley
Источник: Journal of Biophotonics
Ключевые слова: Advancements in Transdermal Drug Delivery, Dermatology and Skin Diseases, Skin Protection and Aging
Другие ссылки: Journal of Biophotonics (PDF)
Journal of Biophotonics (HTML)
PubMed (HTML)