A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variantsстатья из журнала
Аннотация: Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. This brings the number of T2D loci now confidently identified to at least 10.
Год издания: 2007
Авторы: Laura J. Scott, Karen L. Mohlke, Lori L. Bonnycastle, Cristen J. Willer, Yun Li, William L. Duren, Michael R. Erdos, Heather M. Stringham, Peter S. Chines, Anne Jackson, Ludmila Prokunina‐Olsson, Chia-Jen Ding, Amy J. Swift, Narisu Narisu, Tianle Hu, Randall Pruim, Rui Xiao, Xiaoyi Li, Karen N. Conneely, Nancy L. Riebow, Andrew G. Sprau, Maurine Tong, Peggy P. White, Kurt N. Hetrick, Michael W. Barnhart, Craig W. Bark, Janet L. Goldstein, Lee Watkins, Xiang Fang, Jouko Saramies, Thomas A. Buchanan, Richard M. Watanabe, Timo T. Valle, Leena Kinnunen, Gonçalo R. Abecasis, Elizabeth Pugh, Kimberly F. Doheny, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Michael Boehnke
Издательство: American Association for the Advancement of Science
Источник: Science
Ключевые слова: Genetic Associations and Epidemiology, Epigenetics and DNA Methylation, RNA modifications and cancer
Другие ссылки: Science (PDF)
Science (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (PDF)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (HTML)
PubMed (HTML)
Science (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (PDF)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (HTML)
PubMed (HTML)
Открытый доступ: green
Том: 316
Выпуск: 5829
Страницы: 1341–1345