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Prevalence ofhepatitis B virusinfection andcarriage afternineteen years ofvaccination programin the WesternBrazilian Amazon Wornei Silva Miranda BragaMárcia da Costa CastilhoFabiane Giovanella Borges2012 год

Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon
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Аннотация: INTRODUCTION: Reductions in the prevalence of hepatitis B virus (HBV) infection and carriage, decreases in liver cancer incidence, and changes in patterns of liver dysfunctions are described after hepatitis B vaccination. METHODS: We conducted a population-based seroprevalence study aimed at estimating the HBV prevalence and risk of infection in the rural area of Lábrea following nineteen years of HBV vaccination. RESULTS: Half of the subjects showed total anti-HBc of 52.1% (95% CI 49.6-54.7). The HBsAg prevalence was 6.2% (95% CI 5.1-7.6). Multivariate analysis showed an inverse association between HBV infection and vaccination (OR 0.62; 95% CI 0.44-0.87). HBsAg remained independently associated with past hepatitis (OR 2.44; 95% CI 1.52-3.89) and inversely to vaccination (OR 0.43; 95% CI 0.27-0.69). The prevalence of HBeAg among HBsAg-positive individuals was 20.4% (95% CI 12.8-30.1), with the positive subjects having a median age of 11 years (1-46) p=0.0003. CONCLUSIONS: We demonstrate that HBV infection is still an important public health issue and that HBV vaccination could have had better impact on HBV epidemiology. If we extrapolate these findings to other rural areas in the Brazilian Amazon, we can predict that the sources of chronic infected patients remain a challenge. Future studies are needed regarding clinical aspects, molecular epidemiology, surveillance of acute cases, and risk groups.
Год издания: 2012
Авторы: Wornei Silva Miranda Braga, Márcia da Costa Castilho, Fabiane Giovanella Borges, Ana Cristina de Souza Martinho, Ivo Seixas Rodrigues, Eliete Pereira de Azevedo, Márcia Scazufca, Paulo Rossi Menezes
Издательство: Brazilian Society of Tropical Medicine
Источник: Revista da Sociedade Brasileira de Medicina Tropical
Ключевые слова: Hepatitis B Virus Studies, Hepatitis C virus research, Hepatitis Viruses Studies and Epidemiology
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DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
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