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Gross Total ResectionRates in ContemporaryGlioblastoma Surgery Philippe SchuchtJürgen BeckJanine Abu‐Isa2012 год

Gross Total Resection Rates in Contemporary Glioblastoma Surgery
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Complete resection of contrast-enhancing tumor has been recognized as an important prognostic factor in patients with glioblastoma and is a primary goal of surgery. Various intraoperative technologies have recently been introduced to improve glioma surgery.To evaluate the impact of using 5-aminolevulinic acid and intraoperative mapping and monitoring on the rate of complete resection of enhancing tumor (CRET), gross total resection (GTR), and new neurological deficits as part of an institutional protocol.One hundred three consecutive patients underwent resection of glioblastoma from August 2008 to November 2010. Eligibility for CRET was based on the initial magnetic resonance imaging assessed by 2 reviewers. The primary end point was the number of patients with CRET and GTR. Secondary end points were volume of residual contrast-enhancing tissue and new postoperative neurological deficits.Fifty-three patients were eligible for GTR/CRET (n = 43 newly diagnosed glioblastoma, n = 10 recurrent); 13 additional patients received surgery for GTR/CRET-ineligible glioblastoma. GTR was achieved in 96% of patients (n = 51, no residual enhancement >0.175 cm); CRET was achieved in 89% (n = 47, no residual enhancement). Postoperatively, 2 patients experienced worsening of preoperative hemianopia, 1 patient had a new mild hemiparesis, and another patient sustained sensory deficits.Using 5-aminolevulinic acid imaging and intraoperative mapping/monitoring together leads to a high rate of CRET and an increased rate of GTR compared with the literature without increasing the rate of permanent morbidity. The combination of safety and resection-enhancing intraoperative technologies was likely to be the major drivers for this high rate of CRET/GTR.
Год издания: 2012
Авторы: Philippe Schucht, Jürgen Beck, Janine Abu‐Isa, Lukas Andereggen, Michael Murek, Kathleen Seidel, Lennart Stieglitz, Andreas Raabe
Издательство: Lippincott Williams & Wilkins
Источник: Neurosurgery
Ключевые слова: Glioma Diagnosis and Treatment, Meningioma and schwannoma management, Pituitary Gland Disorders and Treatments
Другие ссылки: Neurosurgery (HTML)
PubMed (HTML)