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Course of motor andassociativepallidothalamicprojections inmonkeys Mark S. BaronMamadou Sidib�Mahlon R. DeLong2000 год

Course of motor and associative pallidothalamic projections in monkeys
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Аннотация: As a result of the frequent performance of lesioning and electrical stimulation procedures targeting the globus pallidus internus (GPi) to treat medically intractable hypokinetic and hyperkinetic movement disorders, the course of the pallidothalamic projections originating, in particular, from the motor territory of GPi has important clinical relevancy. To assess the organization of pallidothalamic projections originating from motor and associative portions of GPi, small quantities of the anterograde/ retrograde tracer, biotinylated dextran amine (BDA) were injected into localized regions of the caudal GPi in squirrel monkeys. The localization to motor and associative territories in GPi was confirmed by examining the corresponding regions of retrograde labeling in the striatum and subthalamic nucleus (STN). The labeled pallidothalamic fibers projected principally medially across the inferior edge of the internal capsule. The fiber bundle ventral to the caudal GPi was mainly devoid of labeling. Fibers labeled along the medial and inferior borders of GPi at centrorostral levels were traceable to the medial edge of the injections. The densest fiber labeling at rostral levels was produced by those injections with the greatest extent of rostral labeling of neurons. In opposition to generally accepted schemes, the findings from this study suggest that the pallidothalamic fibers originating from the caudal portions of GPi, including the motor territory, do not course ventromedially to form the ansa lenticularis, but rather, travel predominately medially through the lenticular fasciculus en route to the thalamus. Thus, proposed surgical schemes to target fibers ventral to the caudal GPi or at the rostral pole of GPi appear to be misguided. J. Comp. Neurol. 429:490–501, 2001. © 2000 Wiley-Liss, Inc.
Год издания: 2000
Авторы: Mark S. Baron, Mamadou Sidib�, Mahlon R. DeLong, Yoland Smith
Издательство: Wiley
Источник: The Journal of Comparative Neurology
Ключевые слова: Neurological disorders and treatments, Genetic Neurodegenerative Diseases, Neurological and metabolic disorders
Другие ссылки: The Journal of Comparative Neurology (HTML)
PubMed (HTML)