1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Efficacy ofIgE‐targeted vsempiric six‐foodelimination diets foradult eosinophilicoesophagitis Joaquín Rodríguez‐SánchezElisa Gómez TorrijosBartolomé López Viedma2014 год

Efficacy of IgE‐targeted vs empiric six‐food elimination diets for adult eosinophilic oesophagitis
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Abstract Background Skin testing‐guided elimination diet has proved unsuccessful for adult eosinophilic oesophagitis ( E o E ), whereas empiric six‐food elimination diet ( SFED ) achieves an efficacy of 70%. Objective To compare the efficacy of food‐specific serum I g E ‐targeted elimination diet ( sIgE ‐ ED ) and SFED . Methods Prospective study in adult patients with E o E . Food‐specific serum I g E , skin prick test ( SPT ) and atopy patch test ( APT ) to foods included in SFED were performed. Those with ≥1 positive IgE test, defined by ≥0.1 kU/l, followed a 6‐week sIgE ‐ ED , whereas non‐IgE‐sensitized patients underwent a 6‐week SFED. Responders to diet (<15 eos/HPF) underwent individual reintroduction of foods followed by histological assessment. Results Forty‐three EoE patients were included (26 sIgE ‐ ED and 17 SFED ). Regarding sIgE ‐ ED , the mean number of eliminated foods per patient was significantly lower than in SFED (3.81 vs 6; P < 0.001), being wheat (85%), nuts (73%) and cow's milk (61%) the most commonly foods withdrawn. No difference in histological response was observed between sIgE ‐ ED and SFED (73% vs 53%, P = 0.17). Causative foods identified by food challenge were cow's milk (64%), wheat (28%), egg (21%) and legumes (7%), with a single food trigger in 71% of patients. sIgE exhibited the higher accuracy to predict offending foods in IgE‐sensitized patients (sensitivity 87.5%, specificity 68% ( κ = 0.43)), with k values of 1 for cow's milk. APT results were all negative. Conclusions Histological remission was accomplished in 73% of patients undergoing sIgE ‐ED, which was nonsignificantly superior to SFED . sIgE effectively identified cow's milk as a food trigger in IgE‐sensitized patients.
Год издания: 2014
Авторы: Joaquín Rodríguez‐Sánchez, Elisa Gómez Torrijos, Bartolomé López Viedma, Eva de la Santa Belda, Francisco Martín Dávila, Carmen García Rodríguez, Feo F, J Olmedo Camacho, Pedro Reales Figueroa, Javier Molina‐Infante
Издательство: Wiley
Источник: Allergy
Ключевые слова: Eosinophilic Esophagitis, Eosinophilic Disorders and Syndromes
Другие ссылки: Allergy (PDF)
Allergy (HTML)
PubMed (HTML)