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Genetic disruption ofCYP26B1 severelyaffects developmentof neural crestderived headstructures, but doesnot compromisehindbrain patterning Glenn MacLeanPascal DolléMartin Petkovich2009 год

Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning
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Аннотация: Abstract Cyp26b1 encodes a cytochrome‐P450 enzyme that catabolizes retinoic acid (RA), a vitamin A derived signaling molecule. We have examined Cyp26b1 −/− mice and report that mutants exhibit numerous abnormalities in cranial neural crest cell derived tissues. At embryonic day (E) 18.5 Cyp26b1 −/− animals exhibit a truncated mandible, abnormal tooth buds, reduced ossification of calvaria, and are missing structures of the maxilla and nasal process. Some of these abnormalities may be due to defects in formation of Meckel's cartilage, which is truncated with an unfused distal region at E14.5 in mutant animals. Despite the severe malformations, we did not detect any abnormalities in rhombomere segmentation, or in patterning and migration of anterior hindbrain derived neural crest cells. Abnormal migration of neural crest cells toward the posterior branchial arches was observed, which may underlie defects in larynx and hyoid development. These data suggest different periods of sensitivity of anterior and posterior hindbrain neural crest derivatives to elevated levels of RA in the absence of CYP26B1. Developmental Dynamics 238:732–745, 2009. © 2009 Wiley‐Liss, Inc.
Год издания: 2009
Авторы: Glenn MacLean, Pascal Dollé, Martin Petkovich
Издательство: Wiley
Источник: Developmental Dynamics
Ключевые слова: Cleft Lip and Palate Research, Congenital Ear and Nasal Anomalies, Hedgehog Signaling Pathway Studies
Другие ссылки: Developmental Dynamics (HTML)
PubMed (HTML)