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DefectiveEndothelium-DependentRelaxation inFructose-HypertensiveRats Subodh VermaSanjay BhanotLinfu Yao1996 год

Defective Endothelium-Dependent Relaxation in Fructose-Hypertensive Rats
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Аннотация: The present study examined the endothelium-dependent and -independent responses of isolated mesenteric arteries to acetylcholine and the endothelium-independent vasodilator sodium nitroprusside in mesentede arteries from fructose-induced hypertensive rats. Fructose feeding resulted in hyperinsulinemia and elevated blood pressure when compared to controls (plasma insulin, 5.9 ± 0.4 υ control 3.6 ± 0.4 ng/mL, P < .05; systolic blood pressure, 154 ± 5 υ control 127 ± 7 mm Hg, P < .05). The maximum contractile response of mesenteric arteries to norepinephrine did nol differ between the control and fructose groups, either with or without the endothelium. In arteries with intact endothelia, precontracted with the approximate ED50 of norepinephrine, the percent maximum relaxation produced by acetylcholine in hypertensive rats was lower than the control arteries ( 62 ± 7 υ control 95 ± 5, P < .05) without any change in sensitivity. In arteries precontracted with norepinephrine, the endothelium-independent vasodilator sodium nitroprusside produced a dose-dependent relaxation in arteries obtained from control and fructose groups, both with and without the endothelium. The maximum relaxation produced by sodium nitroprusside did nol differ between control and fructose arteries, either with or without the endothelium; however, removal of the endothelium caused an increase in sensitivity of this agonist. These data suggest that in the insulin resistant and hyperinsulinemie fructose-hypertensive rats, there is a defective endothelium-dependent yet preserved endothelium-independent relaxation. Am J Hyperlens 1996;9:370–376
Год издания: 1996
Авторы: Subodh Verma, Sanjay Bhanot, Linfu Yao, John H. McNeill
Издательство: Oxford University Press
Источник: American Journal of Hypertension
Ключевые слова: Diet, Metabolism, and Disease, Nitric Oxide and Endothelin Effects, Liver Disease Diagnosis and Treatment
Другие ссылки: American Journal of Hypertension (PDF)
American Journal of Hypertension (HTML)
PubMed (HTML)