Аннотация:Abstract: Barrier membranes have become a standard treatment option in alveolar ridge augmentation prior to implant placement. However, non‐resorbable membranes require secondary surgery and resorbable membranes show an unfavorable degradation profile. The purpose of this study was to evaluate the potential of a slowly biodegradable/bioresorbable prototype trilayer membrane (PTLM) for supporting bone regeneration in alveolar ridge augmentation. Clinically relevant cavities were made 3 months after the extraction of the first and second molars in each jaw of six baboons. Each animal was treated with four different regimens: (1) autogenous bone block (ABB) alone, (2) ABB+PTLM, (3) deproteinized bovine bone mineral (DBBM)+PTLM and (4) no treatment. After 9 months, the baboons were sacrificed and block sections of the augmented area were subjected to histologic and histomorphometric analyses. Newly formed bone areas were determined at a distance of 1, 3, 7 and 10 mm from crestal. The data showed a well‐preserved ridge profile at the membrane‐protected sites, whereas non‐protected bone blocks and control sites underwent severe resorption resulting in knife‐edge ridge profiles. Significant differences were found between ABB+PTLM and ABB ( P =0.0137–0.0232). DBBM+PTLM also produced a larger bone area compared with ABB alone ( P =0.0396–0.0439). No significant difference in bone area was detectable between ABB+PTLM and DBBM+PTLM ( P> 0.05). The present study supports the use of the slowly biodegradable/bioresorbable PTLM with autografts and DBBM for lateral ridge augmentation in this type of bone defects.
