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CoCoMac 2.0 and thefuture oftract-tracingdatabases Rembrandt BakkerThomas WächtlerMarkus Diesmann2012 год

CoCoMac 2.0 and the future of tract-tracing databases
статья из журнала

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Аннотация: The CoCoMac database contains the results of several hundred published axonal tract-tracing studies in the macaque monkey brain. The combined results are used for constructing the macaque macro-connectome. Here we discuss the redevelopment of CoCoMac and compare it to six connectome-related projects: two online resources that provide full access to raw tracing data in rodents, a connectome viewer for advanced 3D graphics, a partial but highly detailed rat connectome, a brain data management system that generates custom connectivity matrices, and a software package that covers the complete pipeline from connectivity data to large-scale brain simulations. The second edition of CoCoMac features many enhancements over the original. For example, a search wizard is provided for full access to all tables and their nested dependencies. Connectivity matrices can be computed on demand in a user-selected nomenclature. A new data entry system is available as a preview, and is to become a generic solution for community-driven data entry in manually collated databases. We conclude with the question whether neuronal tracing will remain the gold standard to uncover the wiring of brains, thereby highlighting developments in human connectome construction, tracer substances, polarized light imaging, and serial block-face scanning electron microscopy.
Год издания: 2012
Авторы: Rembrandt Bakker, Thomas Wächtler, Markus Diesmann
Издательство: Frontiers Media
Источник: Frontiers in Neuroinformatics
Ключевые слова: Functional Brain Connectivity Studies, Advanced Neuroimaging Techniques and Applications, Advanced MRI Techniques and Applications
Другие ссылки: Frontiers in Neuroinformatics (PDF)
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Open access LMU (Ludwid Maxmilian's Universitat Munchen) (PDF)
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RWTH Publications (RWTH Aachen) (PDF)
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PubMed Central (HTML)
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