Аннотация:The medical records of 113 patients treated with radiation therapy for invasive cervical cancer between 1975 and 1985 were retrospectively reviewed. Patients with thrombocytosis (platelet count > 400,000/μ1) were compared with those with normal platelet counts. Thrombo-cytosis was present at the initiation of therapy in 20 (17.7%) of the 113 patients. The 5-year cumulative survival rate for the 93 patients with normal platelet counts was 65%, whereas it was 25% for the 20 with thrombocytosis (P < 0.0001, log-rank test). Using Cox's proportional hazards model, thrombocytosis continued to correlate strongly with poor survival even when adjusted for histo-logic type, patient age, and disease stage (P < 0.001). Thrombocytosis is an independent indicator of poor prognosis in patients with cervical cancer.
