1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Significance ofabnormalities indevelopmentaltrajectory andasymmetry of corticalserotonin synthesisin autism Sreenivasa R ChandanaMichael E. BehenCsaba Juhász2004 год

Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Abstract The role of serotonin in prenatal and postnatal brain development is well documented in the animal literature. In earlier studies using positron emission tomography (PET) with the tracer alpha[ 11 C]methyl‐ l ‐tryptophan (AMT), we reported global and focal abnormalities of serotonin synthesis in children with autism. In the present study, we measured brain serotonin synthesis in a large group of autistic children ( n = 117) with AMT PET and related these neuroimaging data to handedness and language function. Cortical AMT uptake abnormalities were objectively derived from small homotopic cortical regions using a predefined cutoff asymmetry threshold (>2 S.D. of normal asymmetry). Autistic children demonstrated several patterns of abnormal cortical involvement, including right cortical, left cortical, and absence of abnormal asymmetry. Global brain values for serotonin synthesis capacity (unidirectional uptake rate constant, K‐complex) values were plotted as a function of age. K‐complex values of autistic children with asymmetry or no asymmetry in cortical AMT uptake followed different developmental patterns, compared to that of a control group of non‐autistic children. The autism groups, defined by presence or absence and side of cortical asymmetry, differed on a measure of language as well as handedness. Autistic children with left cortical AMT decreases showed a higher prevalence of severe language impairment, whereas those with right cortical decreases showed a higher prevalence of left and mixed handedness. Global as well as focal abnormally asymmetric development in the serotonergic system could lead to miswiring of the neural circuits specifying hemispheric specialization.
Год издания: 2004
Авторы: Sreenivasa R Chandana, Michael E. Behen, Csaba Juhász, Otto Muzik, Robert D. Rothermel, Thomas J. Mangner, Pulak K. Chakraborty, Harry T. Chugani, Diane C. Chugani
Издательство: Wiley
Источник: International Journal of Developmental Neuroscience
Ключевые слова: Autism Spectrum Disorder Research, Hemispheric Asymmetry in Neuroscience, Attention Deficit Hyperactivity Disorder
Другие ссылки: International Journal of Developmental Neuroscience (HTML)
Deep Blue (University of Michigan) (PDF)
Deep Blue (University of Michigan) (HTML)
PubMed (HTML)