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DNA methylation: Thenuts and bolts ofrepression Tina Branscombe MirandaPeter A. Jones2007 год

DNA methylation: The nuts and bolts of repression
review

Страница публикацииПубликация в OpenAlex
Аннотация: Abstract DNA methylation is an epigenetic modification which plays an important role in chromatin organization and gene expression. DNA methylation can silence genes and repetitive elements through a process which leads to the alteration of chromatin structure. The mechanisms which target DNA methylation to specific sites in the genome are not fully understood. In this review, we will discuss the mechanisms which lead to the long‐term silencing of genes and will survey the progression that has been made in determining the targeted mechanisms for de novo DNA methylation. J. Cell. Physiol. 213: 384–390, 2007. © 2007 Wiley‐Liss, Inc.
Год издания: 2007
Авторы: Tina Branscombe Miranda, Peter A. Jones
Издательство: Wiley
Источник: Journal of Cellular Physiology
Ключевые слова: Epigenetics and DNA Methylation, Cancer-related gene regulation, Genomics and Chromatin Dynamics
Другие ссылки: Journal of Cellular Physiology (HTML)
PubMed (HTML)