Optical properties of tissue measured using terahertz-pulsed imagingстатья из журнала
Аннотация: The first demonstrations of terahertz imaging in biomedicine were made several years ago, but few data are available on the optical properties of human tissue at terahertz frequencies. A catalogue of these properties has been established to estimate variability and determine the practicality of proposed medical applications in terms of penetration depth, image contrast and reflection at boundaries. A pulsed terahertz imaging system with a useful bandwidth 0.5-2.5 THz was used. Local ethical committee approval was obtained. Transmission measurements were made through tissue slices of thickness 0.08 to 1 mm, including tooth enamel and dentine, cortical bone, skin, adipose tissue and striated muscle. The mean and standard deviation for refractive index and linear attenuation coefficient, both broadband and as a function of frequency, were calculated. The measurements were used in simple models of the transmission, reflection and propagation of terahertz radiation in potential medical applications. Refractive indices ranged from 1.5 ± 0.5 for adipose tissue to 3.06 ± 0.09 for tooth enamel. Significant differences (P < 0.05) were found between the broadband refractive indices of a number of tissues. Terahertz radiation is strongly absorbed in tissue so reflection imaging, which has lower penetration requirements than transmission, shows promise for dental or dermatological applications.
Год издания: 2003
Авторы: Elizabeth Berry, Anthony J. Fitzgerald, N. N. Zinov’ev, Gillian C. Walker, Shervanthi Homer‐Vanniasinkam, Caroline D. Sudworth, R.E. Miles, J.M. Chamberlain, Michael A. Smith
Издательство: SPIE
Источник: Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Ключевые слова: Terahertz technology and applications, Optical and Acousto-Optic Technologies, Infrared Thermography in Medicine
Другие ссылки: Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (HTML)
White Rose Research Online (University of Leeds) (HTML)
White Rose Research Online (University of Leeds) (HTML)
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