ANTITUBERCULOUS EFFECTS OF CERTAIN SURFACE‐ACTIVE POLYOXYETHYLENE ETHERSстатья из журнала
Аннотация: We have previously reported (Cornforth, Hart, Rees, and Stock, 1951) that a commercial surfaceactive agent, the non-ionic " Triton A20 " (Rohm and Haas Co., Philadelphia),* has a suppressive effect on experimental tuberculosis in the mouse, and that the effect is shared by a number of simi- larly constituted products prepared by ourselves.These observations introduced a new type of anti- tuberculous agent.Furthermore, since the thera- peutically active products failed to inhibit the multiplication of tubercle bacilli in vitro, it was suggested that they might in some way modify the host's response to a tuberculous infection (Rees, 1953).The antituberculous properties of Triton A20 have been confirmed by Solotorovsky and Gregory (1952), who also reported a synergistic action with dihydrostreptomycin in a mouse infection.In addition to suppressing acute tuberculosis in mice, these agents can produce appreciable re- gression and healing of an established infection in the guinea-pig (Rees, 1953).The present paper supplies necessary details of the earlier work and describes further developments.Some of the results were briefly communicated by Cornforth, Hart, Nicholls, and Rees (1953). CHEMICAL SECTION CHEMICAL NATURE OF PRODUCTSOur first experiments, which were based on a chemical examination of Triton A20, and which resembled procedures given in U.S. Patent No. 2,454,541, involved acid-catalysed condensation of p-(l :1:3:3tetramethylbutyl)phenol (I; referred to henceforward as octylphenol) with formaldehyde, followed by heat treatment of the product and reaction of the resulting resin with 17 to 20 molecules of ethylene oxide for each phenolic group.The final product, a watersoluble syrup, differed slightly in some of its properties from Triton A20, but proved equally effective against experimental tuberculosis in the mouse.* The solute, of which Triton A20 is an aqueous solution, is known as WR1339
Год издания: 1955
Издательство: Wiley
Источник: British Journal of Pharmacology and Chemotherapy
Ключевые слова: Cancer Treatment and Pharmacology, Click Chemistry and Applications
Другие ссылки: British Journal of Pharmacology and Chemotherapy (HTML)
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Том: 10
Выпуск: 1
Страницы: 73–86