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Oxygen modifiesarterydifferentiation andnetwork morphogenesisin the retinalvasculature Suzanne ClaxtonMarcus Fruttiger2005 год

Oxygen modifies artery differentiation and network morphogenesis in the retinal vasculature
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Аннотация: Abstract The mechanisms that control differentiation of immature blood vessels into either arteries or veins are not well understood. Because oxygen tension in arteries is higher than in veins, oxygen has the potential to be an instructive signal for artery/vein (AV) differentiation. We test this hypothesis by exposing newborn mice to moderate hypoxia (10% atmospheric oxygen) and studying AV differentiation in the developing retinal vasculature. Forming retinal arteries fail to express the artery‐specific markers Delta‐like 4 (Dll4) and EphrinB2 during hypoxia. However, other aspects of AV differentiation are retained such as high levels of alpha smooth muscle actin in arterial mural cells and vein‐specific expression of the msr/apj gene. The capillary network between arteries and veins is denser, and capillaries expressing the venous marker msr/apj are found in territories normally occupied by arterial capillaries. Thus, it appears that high oxygen in arterial blood is required for arterial expression of Dll4 and EphrinB2, which could be involved in cell–cell repulsion pathways that dictate the normal segregation of arteries and veins. Developmental Dynamics 233:822–828, 2005. © 2005 Wiley‐Liss, Inc.
Год издания: 2005
Авторы: Suzanne Claxton, Marcus Fruttiger
Издательство: Wiley
Источник: Developmental Dynamics
Ключевые слова: Zebrafish Biomedical Research Applications, Axon Guidance and Neuronal Signaling, Angiogenesis and VEGF in Cancer
Другие ссылки: Developmental Dynamics (HTML)
PubMed (HTML)