Аннотация:Transforming growth factor-β (TGFβ) regulates cell cycle progression by a unique signaling mechanism that involves its binding to the type II (TβR-II) TGFβ receptor and activation of type I (TβR-I). Both are transmembrane serine-threonine receptor kinases. As various types of human tumor cells are often refractory to TGFβ-mediated cell cycle arrest, it is likely that the TβR-I receptor is inactivated in many of these cases. We determined the intron–exon organization of theTGFBR1gene. We report here that this gene is approximately 31 kb in length and consists of nine exons. The organization of the segment of theTGFBR1gene that encodes the C-terminal portion of the serine-threonine kinase domain appears to be highly conserved between members of the R-I gene family. This information should facilitate and expedite the structural analysis ofTGFBR1in human tumors and possibly other disease states.
