1. Главная
  2. Ресурсы
  3. Библиотечный поиск
The Analysis ofFailure Times in thePresence of CompetingRisks Ross L. PrenticeJohn D. KalbfleischArthur V. Peterson1978 год

The Analysis of Failure Times in the Presence of Competing Risks
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Distinct problems in the analysis of failure times with competing causes of failure include the estimation of treatment or exposure effects on specific failure types, the study of interrelations among failure types, and the estimation of failure rates for some causes given the removal of certain other failure types. The usual formation of these problems is in terms of conceptual or latent failure times for each failure type. This approach is criticized on the basis of unwarranted assumptions, lack of physical interpretation and identifiability problems. An alternative approach utilizing cause-specific hazard functions for observable quantities, including time-dependent covariates, is proposed. Cause-specific hazard functions are shown to be the basic estimable quantities in the competing risks framework. A method, involving the estimation of parameters that relate time-dependent risk indicators for some causes to cause-specific hazard functions for other causes, is proposed for the study of interrelations among failure types. Further, it is argued that the problem of estimation of failure rates under the removal of certain causes is not well posed until a mechanism for cause removal is specified. Following such a specification, one will sometimes be in a position to make sensible extrapolations from available data to situations involving cause removal. A clinical program in bone marrow transplantation for leukemia provides a setting for discussion and illustration of each of these ideas. Failure due to censoring in a survivorship study leads to further discussion.
Год издания: 1978
Авторы: Ross L. Prentice, John D. Kalbfleisch, Arthur V. Peterson, Nancy Flournoy, Vernon T. Farewell, N. E. Breslow
Издательство: Oxford University Press
Источник: Biometrics
Ключевые слова: Statistical Methods in Clinical Trials, Health Systems, Economic Evaluations, Quality of Life, Statistical Methods and Inference
Другие ссылки: Biometrics (HTML)
PubMed (HTML)