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Study of threepatients withthromboticthrombocytopenicpurpura exchangedwithsolvent/detergent-treated plasma Rachel FlamholzHyeran Helen JeonJoseph M. Baron2000 год

Study of three patients with thrombotic thrombocytopenic purpura exchanged with solvent/detergent-treated plasma: Is its decreased protein S activity clinically related to their development of deep venous thromboses?
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Аннотация: Solvent/detergent treated plasma (S/DP) has reduced protein S activity (about 0.5 units/mL) as compared with fresh frozen plasma (FFP). When used as replacement fluid for repetitive therapeutic plasma exchange (PEX), e.g., in patients with thrombotic thrombocytopenic purpura (TTP), S/DP could lead to lowered protein S levels and, possibly, risk of hypercoagulable complications. We describe three patients with TTP who had low functional protein S (FPS) levels during PEX for TTP. Each developed one or more deep vein thromboses (DVTs) while receiving 100% S/DP or 50% S/DP and 50% cryosupernatant plasma (CSP) as replacement fluid. FPS levels rose when 100% CSP was substituted for S/DP. Our observations suggest that use of S/DP alone or in 50% combination with CSP as replacement fluid in PEX for TTP may lead to difficulty in maintaining safe FPS levels. Determination of risk of resulting clinically significant thrombotic events requires further study. J. Clin. Apheresis 15:169–172, 2000. © 2000 Wiley-Liss, Inc.
Год издания: 2000
Авторы: Rachel Flamholz, Hyeran Helen Jeon, Joseph M. Baron, Beverly W. Baron
Издательство: Wiley
Источник: Journal of Clinical Apheresis
Ключевые слова: Complement system in diseases, Platelet Disorders and Treatments, Blood Coagulation and Thrombosis Mechanisms
Другие ссылки: Journal of Clinical Apheresis (HTML)
PubMed (HTML)