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Fulminant Hepatitis Ein Japan Kazuyuki SuzukiTatsuya AikawaHiroaki Okamoto2002 год

Fulminant Hepatitis E in Japan
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Аннотация: In the Women's Contraceptive and Reproductive Experiences (Women's CARE) Study, Marchbanks et al. (June 27 issue) 1 carefully verified previous investigations showing that there is no association between combination oral contraceptives and the risk of breast cancer among women older than 45 years of age. 2 However, when data from women 35 to 44 years old are combined for analysis, the risk of breast cancer associated with recent use of oral contraceptives may not be fully apparent among the youngest women.The investigators report that they found a higher risk of breast cancer among the women 35 to 39 years old than among the older women.However, because the risk of breast cancer associated with recent oral-contraceptive use is greatest among very young women, 2 and may be twice that among nonusers in some subgroups, 2,3 closer examination of the women 35 to 39 years old in this study is warranted.Although oral-contraceptive use does not appear to increase the risk of breast cancer among older women, the findings need to be interpreted within the context of risk over the course of a lifetime.For example, oral contraceptives may cause nascent tumors to become clinically evident earlier in women who use contraceptives than in those who do not.Consequently, oral-contraceptive users in whom cancer does not develop at a young age (e.g., before the age of 40 years) may be less susceptible at older ages to the promotional effects of oral contraceptives.The results of the Women's CARE Study sparked media reports that oral contraceptives should no longer be considered a risk factor for breast can-cer, when in fact there may be some evidence that recent use increases risk in very young women.
Год издания: 2002
Авторы: Kazuyuki Suzuki, Tatsuya Aikawa, Hiroaki Okamoto
Издательство: Massachusetts Medical Society
Источник: New England Journal of Medicine
Ключевые слова: Hepatitis Viruses Studies and Epidemiology, Liver Disease and Transplantation, Viral gastroenteritis research and epidemiology
Другие ссылки: New England Journal of Medicine (PDF)
New England Journal of Medicine (HTML)
PubMed (HTML)