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MULTISESSIONCYBERKNIFESTEREOTACTICRADIOSURGERY OFLARGE, BENIGN CRANIALBASE TUMORS Francesco TunizScott G. SoltysClara Y.H. Choi2009 год

MULTISESSION CYBERKNIFE STEREOTACTIC RADIOSURGERY OF LARGE, BENIGN CRANIAL BASE TUMORS
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Although radiosurgery plays an important role in managing benign cranial base lesions, the potential for increased toxicity with single-session treatment of large tumors is a concern. In this retrospective study, we report the intermediate-term rate of local control, morbidity, and clinical outcomes of patients with large cranial base tumors treated with multisession stereotactic radiosurgery with the CyberKnife (Accuray, Inc., Sunnyvale, CA).Between 1999 and 2008, 34 consecutive patients with large (>15 cm), benign cranial base tumors (21 meningiomas, 9 schwannomas, 4 glomus jugulare tumors) underwent primary or postoperative radiosurgical treatment using a multisession approach at Stanford University and were considered in this retrospective study. Forty-four percent of these patients had undergone previous subtotal surgical resection or radiotherapy. CyberKnife radiosurgery was delivered in 2 to 5 sessions (median, 3 sessions) to a median tumor volume of 19.3 cm (range, 15.8-69.3 cm). The median marginal dose was 24 Gy (range, 18-25 Gy) prescribed to a median 78% isodose line.After a median clinical follow-up of 31 months (range, 12-77 months), 21% of patients experienced clinical improvement of neurological symptoms, whereas neurological status remained unchanged among the rest. Four patients experienced prolonged use of glucocorticoids owing to transient neurological worsening and radiographic signs of radiation injury. No permanent neurotoxicity was seen. To date, all tumors remain locally controlled.Over our modest length of follow-up, multisession radiosurgery appears to be a safe and effective option for selected large, benign brain and cranial base lesions.
Год издания: 2009
Авторы: Francesco Tuniz, Scott G. Soltys, Clara Y.H. Choi, Steven D. Chang, Iris C. Gibbs, Nancy J. Fischbein, John R. Adler
Издательство: Lippincott Williams & Wilkins
Источник: Neurosurgery
Ключевые слова: Meningioma and schwannoma management, Adrenal and Paraganglionic Tumors, Neurofibromatosis and Schwannoma Cases
Другие ссылки: Neurosurgery (HTML)
PubMed (HTML)