1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Effective Treatmentof Chronic Low BackPain in HumansReverses AbnormalBrain Anatomy andFunction David A. SeminowiczTimothy H. WidemanLina Naso2011 год

Effective Treatment of Chronic Low Back Pain in Humans Reverses Abnormal Brain Anatomy and Function
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Chronic pain is associated with reduced brain gray matter and impaired cognitive ability. In this longitudinal study, we assessed whether neuroanatomical and functional abnormalities were reversible and dependent on treatment outcomes. We acquired MRI scans from chronic low back pain (CLBP) patients before ( n = 18) and 6 months after (spine surgery or facet joint injections; n = 14) treatment. In addition, we scanned 16 healthy controls, 10 of which returned 6 months after the first visit. We performed cortical thickness analysis on structural MRI scans, and subjects performed a cognitive task during the functional MRI. We compared patients and controls, as well as patients before versus after treatment. After treatment, patients had increased cortical thickness in the left dorsolateral prefrontal cortex (DLPFC), which was thinner before treatment compared with controls. Increased DLPFC thickness correlated with the reduction of both pain and physical disability. Additionally, increased thickness in primary motor cortex was associated specifically with reduced physical disability, and right anterior insula was associated specifically with reduced pain. Left DLPFC activity during an attention-demanding cognitive task was abnormal before treatment, but normalized following treatment. These data indicate that functional and structural brain abnormalities—specifically in the left DLPFC—are reversible, suggesting that treating chronic pain can restore normal brain function in humans.
Год издания: 2011
Авторы: David A. Seminowicz, Timothy H. Wideman, Lina Naso, Zeinab Hatami-Khoroushahi, Summaya Fallatah, Mark A. Ware, Peter Jarzem, M. Catherine Bushnell, Yoram Shir, Jean Ouellet, Laura S. Stone
Издательство: Society for Neuroscience
Источник: Journal of Neuroscience
Ключевые слова: Musculoskeletal pain and rehabilitation, Pain Mechanisms and Treatments, Pain Management and Placebo Effect
Другие ссылки: Journal of Neuroscience (PDF)
Journal of Neuroscience (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)