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Type I Collagen α1Sp1 Polymorphism andthe Risk of CruciateLigament Ruptures orShoulder Dislocations Shwan KhoschnauHåkan MelhusA. Jacobson2008 год

Type I Collagen α1 Sp1 Polymorphism and the Risk of Cruciate Ligament Ruptures or Shoulder Dislocations
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Аннотация: Cruciate ligament ruptures and shoulder dislocations are often caused by trauma, but predisposing intrinsic factors might also influence the risk. These injuries are more common in those with a previously injured sibling, an observation that might indicate a genetic predisposition. It is well known that polymorphisms in the collagen I gene are associated not only with osteoporosis and osteoporotic fracture risk, but also with osteoarthritis.Because collagen I is abundant in ligaments and tendons, the authors hypothesized that collagen I alpha1 Sp1 polymorphism also was related to the occurrence of cruciate ligament ruptures and shoulder dislocations.Case-control study; Level of evidence, 3.A total of 358 patients and 325 randomly selected population-based female controls were included in the study. Of the cases, 233 had a cruciate ligament rupture and 126 had had a shoulder dislocation. Age-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) estimated by unconditional logistic regression were used as measures of association.Compared with the homozygous SS category, the heterozygous participants displayed a similar risk (OR, 1.06; 95% CI, 0.76-1.49), whereas the ss genotype was underrepresented in the injured population compared with the controls (OR, 0.15; 95% CI, 0.03-0.68). This latter estimate was similar for both cruciate ligament ruptures and shoulder dislocations, and was furthermore not modified by general joint laxity.The authors found a substantially decreased risk of these injuries associated with collagen type I alpha1 Sp1 polymorphism. The study might encourage other investigators to consider further research in the area of genes and soft tissue injuries.
Год издания: 2008
Авторы: Shwan Khoschnau, Håkan Melhus, A. Jacobson, Hans Rahme, Henrik Bengtsson, Eva Ribom, Elin Grundberg, Hans Mallmin, Karl Michaëlsson
Издательство: SAGE Publishing
Источник: The American Journal of Sports Medicine
Ключевые слова: Knee injuries and reconstruction techniques, Tendon Structure and Treatment, Orthopedic Surgery and Rehabilitation
Другие ссылки: The American Journal of Sports Medicine (HTML)
PubMed (HTML)