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Differential efficacyof escitalopram andnortriptyline ondimensional measuresof depression Rudolf UherWolfgang MaierJoanna Hauser2009 год

Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression
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Аннотация: Background Tricyclic antidepressants and serotonin reuptake inhibitors are considered to be equally effective, but differences may have been obscured by internally inconsistent measurement scales and inefficient statistical analyses. Aims To test the hypothesis that escitalopram and nortriptyline differ in their effects on observed mood, cognitive and neurovegetative symptoms of depression. Method In a multicentre part-randomised open-label design (the Genome Based Therapeutic Drugs for Depression (GENDEP) study) 811 adults with moderate to severe unipolar depression were allocated to flexible dosage escitalopram or nortriptyline for 12 weeks. The weekly Montgomery–Åsberg Depression Rating Scale, Hamilton Rating Scale for Depression, and Beck Depression Inventory were scored both conventionally and in a more novel way according to dimensions of observed mood, cognitive symptoms and neurovegetative symptoms. Results Mixed-effect linear regression showed no difference between escitalopram and nortriptyline on the three original scales, but symptom dimensions revealed drug-specific advantages. Observed mood and cognitive symptoms improved more with escitalopram than with nortriptyline. Neurovegetative symptoms improved more with nortriptyline than with escitalopram. Conclusions The three symptom dimensions provided sensitive descriptors of differential antidepressant response and enabled identification of drug-specific effects.
Год издания: 2009
Авторы: Rudolf Uher, Wolfgang Maier, Joanna Hauser, Andrej Marušič†, Christine Schmael, Ole Mors, Neven Henigsberg, Daniel Souery, Anna Placentino, Marcella Rietschel, Astrid Zobel, Monika Dmitrzak‐Węglarz, Ana Tomás, Lisbeth Flindt Jørgensen, Petra Kalember, C Giovannini, Mara Barreto, Amanda Elkin, Sabine Landau, Anne Farmer, Katherine J. Aitchison, Peter McGuffin
Издательство: Cambridge University Press
Источник: The British Journal of Psychiatry
Ключевые слова: Treatment of Major Depression, Tryptophan and brain disorders, Mental Health Research Topics
Другие ссылки: The British Journal of Psychiatry (PDF)
The British Journal of Psychiatry (HTML)
PubMed (HTML)