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Treatment of KneeOsteoarthritis WithAllogeneic BoneMarrow MesenchymalStem Cells Aurelio VegaMiguel Ángel Martín-FerreroFrancisco Del Canto2015 год

Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Osteoarthritis is the most prevalent joint disease and a common cause of joint pain, functional loss, and disability. Conventional treatments demonstrate only modest clinical benefits without lesion reversal. Autologous mesenchymal stromal cell (MSC) treatments have shown feasibility, safety, and strong indications for clinical efficacy. We performed a randomized, active control trial to assess the feasibility and safety of treating osteoarthritis with allogeneic MSCs, and we obtain information regarding the efficacy of this treatment.We randomized 30 patients with chronic knee pain unresponsive to conservative treatments and showing radiological evidence of osteoarthritis into 2 groups of 15 patients. The test group was treated with allogeneic bone marrow MSCs by intra-articular injection of 40 × 10(6) cells. The control group received intra-articular hyaluronic acid (60 mg, single dose). Clinical outcomes were followed for 1 year and included evaluations of pain, disability, and quality of life. Articular cartilage quality was assessed by quantitative magnetic resonance imaging T2 mapping.Feasibility and safety were confirmed and indications of clinical efficacy were identified. The MSC-treated patients displayed significant improvement in algofunctional indices versus the active controls treated with hyaluronic acid. Quantification of cartilage quality by T2 relaxation measurements showed a significant decrease in poor cartilage areas, with cartilage quality improvements in MSC-treated patients.Allogeneic MSC therapy may be a valid alternative for the treatment of chronic knee osteoarthritis that is more logistically convenient than autologous MSC treatment. The intervention is simple, does not require surgery, provides pain relief, and significantly improves cartilage quality.
Год издания: 2015
Авторы: Aurelio Vega, Miguel Ángel Martín-Ferrero, Francisco Del Canto, Mercedes Alberca, Verónica García, Anna Munar, Lluís Orozco, Robert Soler, Juan J. Fuertes, Marina Huguet, Ana Sánchez, Javier Garcı́a-Sancho
Издательство: Wolters Kluwer
Источник: Transplantation
Ключевые слова: Mesenchymal stem cell research, Osteoarthritis Treatment and Mechanisms, Wound Healing and Treatments
Другие ссылки: Transplantation (HTML)
journals.lww.com (HTML)
PubMed (HTML)