1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Nitric oxide‐mediatedmetabolic regulationduring exercise:effects of trainingin health andcardiovasculardisease Bronwyn A. Kingwell2000 год

Nitric oxide‐mediated metabolic regulation during exercise: effects of training in health and cardiovascular disease
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Accumulating data suggest that nitric oxide (NO) is important for both coronary and peripheral hemodynamic control and metabolic regulation during exercise. Although still controversial, NO of endothelial origin may potentiate exercise-induced hyperemia. Mechanisms of release include both acetylcholine derived from the neuromuscular junction and elevation in vascular shear stress. A splice variant of neuronal nitric oxide synthase (NOS), nNOSμ, is expressed in human skeletal muscle. In addition to being a potential modulator of blood flow, NO from skeletal muscle regulates muscle contraction and metabolism. In particular, recent human data indicate that NO plays a role in muscle glucose uptake during exercise independently of blood flow. Exercise training in healthy individuals elevates NO bioavailability through a variety of mechanisms including increased NOS enzyme expression and activity. Such adaptations likely contribute to increased exercise capacity and cardiovascular protection. Cardiovascular risk factors including hypercholesterolemia, hypertension, diabetes, and smoking as well as established disease are associated with impairment of the various NO systems. Given that NO is an important signaling mechanism during exercise, such impairment may contribute to limitations in exercise capacity through inadequate coronary or peripheral perfusion and via metabolic effects. Exercise training in individuals with elevated cardiovascular risk or established disease can increase NO bioavailability and may represent an important mechanism by which exercise training conveys benefit in the setting of secondary prevention.— Kingwell, B. A. Nitric oxide-mediated metabolic regulation during exercise: effects of training in health and cardiovascular disease. FASEB J. 14, 1685–1696 (2000)
Год издания: 2000
Авторы: Bronwyn A. Kingwell
Издательство: Wiley
Источник: The FASEB Journal
Ключевые слова: Nitric Oxide and Endothelin Effects, Heart Rate Variability and Autonomic Control, Cardiovascular and exercise physiology
Другие ссылки: The FASEB Journal (PDF)
The FASEB Journal (HTML)
PubMed (HTML)