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Revisiting theGenetic Ancestry ofBrazilians UsingAutosomal AIM-Indels Fernanda Saloum de Neves MantaRui PereiraRomulo Vianna2013 год

Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: There are many different studies that contribute to the global picture of the ethnic heterogeneity in Brazilian populations. These studies use different types of genetic markers and are focused on the comparison of populations at different levels. In some of them, each geographical region is treated as a single homogeneous population, whereas other studies create different subdivisions: political (e.g., pooling populations by State), demographic (e.g., urban and rural), or ethnic (e.g., culture, self-declaration, or skin colour). In this study, we performed an enhanced reassessment of the genetic ancestry of ~ 1,300 Brazilians characterised for 46 autosomal Ancestry Informative Markers (AIMs). In addition, 798 individuals from twelve Brazilian populations representing the five geographical macro-regions of Brazil were newly genotyped, including a Native American community and a rural Amazonian community. Following an increasing North to South gradient, European ancestry was the most prevalent in all urban populations (with values up to 74%). The populations in the North consisted of a significant proportion of Native American ancestry that was about two times higher than the African contribution. Conversely, in the Northeast, Center-West and Southeast, African ancestry was the second most prevalent. At an intrapopulation level, all urban populations were highly admixed, and most of the variation in ancestry proportions was observed between individuals within each population rather than among population. Nevertheless, individuals with a high proportion of Native American ancestry are only found in the samples from Terena and Santa Isabel. Our results allowed us to further refine the genetic landscape of Brazilians while establishing the basis for the effective application of an autosomal AIM panel in forensic casework and clinical association studies within the highly admixed Brazilian populations.
Год издания: 2013
Авторы: Fernanda Saloum de Neves Manta, Rui Pereira, Romulo Vianna, Alfredo Rodolfo Beuttenmüller de Araújo, Daniel Leite Góes Gitaí, Silva Da, Eldamária de Vargas Wolfgramm, Isabel da Mota Pontes, José Ivan Albuquerque Aguiar, Milton Ozório Moraes, Elizeu Fagundes de Carvalho, Leonor Gusmão
Издательство: Public Library of Science
Источник: PLoS ONE
Ключевые слова: Forensic and Genetic Research, Race, Genetics, and Society, Molecular Biology Techniques and Applications
Другие ссылки: PLoS ONE (PDF)
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DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Americanae (AECID Library) (PDF)
Americanae (AECID Library) (HTML)
PubMed Central (HTML)
PubMed (HTML)