Cost-effective use of prereferral treatment for severe malariaписьмо
Аннотация: Notwithstanding the optimism surrounding falling malaria transmission, the harsh reality for billions of people in endemic areas remains that, where access to health facilities is poor, this otherwise curable disease can rapidly deteriorate to severe illness and death. 1 WHOThe World malaria report 2009. http://www.who.int/malaria/world_malaria_report_2009/en/index.htmlDate: 2009 Google Scholar , 2 Feachem R Sabot O A new global malaria eradication strategy. Lancet. 2008; 371: 1633-1635 Summary Full Text Full Text PDF PubMed Scopus (152) Google Scholar In The Lancet, Yeşim Tozan and colleagues 3 Tozan Y Klein EY Darley S Panicker R Laxminarayan R Breman JG Prereferral rectal artesunate for treatment of severe childhood malaria: a cost-effective analysis. Lancet. 2010; (published online Nov 29. DOI:S0140-6736(10)61460-2) PubMed Google Scholar describe the cost-effectiveness of prereferral rectal artesunate in children with severe malaria. The rationale is that the administration of an effective antimalarial suppository can halt malaria progression until the patient reaches facilities where parenteral treatment is available. Prereferral use of artesunate was investigated by Gomes and colleagues, 4 Gomes MF Faiz MA Gyapong JO et al. for the Study 13 Research GroupPre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet. 2009; 373: 557-566 Summary Full Text Full Text PDF PubMed Scopus (168) Google Scholar who found that, for patients who face extensive delays in attending health facilities, this intervention significantly reduced mortality and severe disability. For patients living closer to a health facility, there was no evidence of advantage in the use of prereferral artesunate. This finding would be expected in view of the 6–12 h required for artesunate to reduce parasitaemia. Prereferral rectal artesunate for treatment of severe childhood malaria: a cost-effectiveness analysisPrereferral artesunate treatment is a cost-effective, life-saving intervention, which can substantially improve the management of severe childhood malaria in rural African settings in which programmes for community health workers are in place. Full-Text PDF
Год издания: 2010
Авторы: Yoel Lubell
Источник: The Lancet
Ключевые слова: Malaria Research and Control, Mosquito-borne diseases and control, Global Maternal and Child Health
Другие ссылки: The Lancet (HTML)
PubMed (HTML)
PubMed (HTML)
Открытый доступ: closed
Том: 376
Выпуск: 9756
Страницы: 1880–1881