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Embryonic left–rightseparation mechanismallows confinement ofmutation‐inducedphenotypes to onelateral body half ofbilaterians Kun Ma2013 год

Embryonic left–right separation mechanism allows confinement of mutation‐induced phenotypes to one lateral body half of bilaterians
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: A fundamental question in developmental biology is how a chimeric animal such as a bilateral gynandromorphic animal can have different phenotypes confined to different lateral body halves, and how mutation‐induced phenotypes, such as genetic diseases, can be confined to one lateral body half in patients. Here, I propose that embryos of many, if not all, bilaterian animals are divided into left and right halves at a very early stage (which may vary among different types of animals), after which the descendants of the left‐sided and right‐sided cells will almost exclusively remain on their original sides, respectively, throughout the remaining development. This embryonic left–right separation mechanism allows (1) mutations and the mutation‐induced phenotypes to be strictly confined to one lateral body half in animals and humans; (2) mothers with bilateral hereditary primary breast cancer to transmit their disease to their offspring at twofold of the rate compared to mothers with unilateral hereditary breast cancer; and (3) a mosaic embryo carrying genetic or epigenetic mutations to develop into either an individual with the mutation‐induced phenotype confined unilaterally, or a pair of twins displaying complete, partial, or mirror‐image discordance for the phenotype. Further, this left–right separation mechanism predicts that the two lateral halves of a patient carrying a unilateral genetic disease can each serve as a case and an internal control, respectively, for genetic and epigenetic comparative studies to identify the disease causations. © 2013 Wiley Periodicals, Inc.
Год издания: 2013
Авторы: Kun Ma
Издательство: Wiley
Источник: American Journal of Medical Genetics Part A
Ключевые слова: Hedgehog Signaling Pathway Studies, Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities, Genomic variations and chromosomal abnormalities
Другие ссылки: American Journal of Medical Genetics Part A (HTML)
PubMed (HTML)