1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Liver fibrosis:non‐invasiveassessment with MRelastography Laurent HuwartFrank PeetersRalph Sinkus2006 год

Liver fibrosis: non‐invasive assessment with MR elastography
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Abstract The aim of this study was to assess the feasibility of using non‐invasive MR elastography for determining the stage of liver fibrosis. Twenty‐five consecutive patients who had liver biopsy for suspicion of chronic liver disease were included in the study. The stage of fibrosis on the biopsies was assessed according to the METAVIR scoring system from F0, no fibrosis, to F4, cirrhosis. MR elastography was performed by transmitting low‐frequency (65 Hz) mechanical waves into the liver with a transducer placed at the back of the patients. The MR pulse sequence was a motion‐sensitized spin‐echo sequence, phase‐locked to the mechanical excitation. The phase maps were processed to obtain shear elasticity and shear viscosity maps. The mean hepatic shear elasticity increased with increasing stage of fibrosis. The mean elasticity was 2.24 ± 0.23 kPa in the 11 patients without substantial fibrosis (F0–F1 grades), 2.56 ± 0.24 kPa in the four patients with substantial fibrosis (F2–F3) and 4.68 ± 1.61 kPa in the 10 patients with cirrhosis (F4). The differences between groups were statistically significant ( p ≤ 0.05). The mean shear viscosity was significantly higher in the patients with cirrhosis (5.19 ± 1.85 Pa · s) than in the patients without cirrhosis (2.39 ± 0.86 Pa · s in F0–F1 and 2.27 ± 0.38 Pa · s in F2–F3 patients). It is concluded that non‐invasive MR elastography is a feasible method to assess the stage of liver fibrosis. Copyright © 2006 John Wiley & Sons, Ltd.
Год издания: 2006
Авторы: Laurent Huwart, Frank Peeters, Ralph Sinkus, Laurence Annet, Najat Salameh, Leon C. ter Beek, Yves Horsmans, Bernard E. Van Beers
Издательство: Wiley
Источник: NMR in Biomedicine
Ключевые слова: Liver Disease Diagnosis and Treatment, Hepatocellular Carcinoma Treatment and Prognosis, Animal Virus Infections Studies
Другие ссылки: NMR in Biomedicine (HTML)
PubMed (HTML)