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Relationship BetweenIntravascularUltrasound Guidanceand Clinical OutcomesAfter Drug-ElutingStents Bernhard WitzenbichlerAkiko MaeharaGiora Weisz2013 год

Relationship Between Intravascular Ultrasound Guidance and Clinical Outcomes After Drug-Eluting Stents
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Аннотация: Background— Prior small to modest-sized studies suggest a benefit of intravascular ultrasound (IVUS) guidance in noncomplex lesions. Whether IVUS guidance is associated with improved clinical outcomes after drug-eluting stent (DES) implantation in an unrestricted patient population is unknown. Methods and Results— Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents (ADAPT-DES) was a prospective, multicenter, nonrandomized “all-comers” study of 8583 consecutive patients at 11 international centers designed to determine the frequency, timing, and correlates of stent thrombosis and adverse clinical events after DES. Propensity-adjusted multivariable analysis was performed to examine the relationship between IVUS guidance and 1-year outcomes. IVUS was utilized in 3349 patients (39%), and larger-diameter devices, longer stents, and/or higher inflation pressures were used in 74% of IVUS-guided cases. IVUS guidance compared with angiography guidance was associated with reduced 1-year rates of definite/probable stent thrombosis (0.6% [18 events] versus 1.0% [53 events]; adjusted hazard radio, 0.40; 95% confidence interval, 0.21–0.73; P =0.003), myocardial infarction (2.5% versus 3.7%; adjusted hazard radio, 0.66; 95% confidence interval, 0.49–0.88; P =0.004), and composite adjudicated major adverse cardiac events (ie, cardiac death, myocardial infarction, or stent thrombosis) (3.1% versus 4.7%; adjusted hazard radio, 0.70; 95% confidence interval, 0.55–0.88; P =0.002). The benefits of IVUS were especially evident in patients with acute coronary syndromes and complex lesions, although significant reductions in major adverse cardiac events were present in all patient subgroups those with including stable angina and single-vessel disease. Conclusions— In ADAPT-DES, the largest study of IVUS use to date, IVUS guidance was associated with a reduction in stent thrombosis, myocardial infarction, and major adverse cardiac events within 1 year after DES implantation. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00638794.
Год издания: 2013
Авторы: Bernhard Witzenbichler, Akiko Maehara, Giora Weisz, Franz‐Josef Neumann, Michael J. Rinaldi, D. Christopher Metzger, Timothy D. Henry, David A. Cox, Peter L. Duffy, Bruce R. Brodie, Thomas Stuckey, Ernest L. Mazzaferri, Ke Xu, Helen Parise, Roxana Mehran, Gary S. Mintz, Gregg W. Stone
Издательство: Lippincott Williams & Wilkins
Источник: Circulation
Ключевые слова: Coronary Interventions and Diagnostics, Peripheral Artery Disease Management, Vascular Procedures and Complications
Другие ссылки: Circulation (PDF)
Circulation (HTML)
PubMed (HTML)