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Intranasal Mupirocinto PreventPostoperativeStaphylococcusaureusInfections Trish M. PerlJoseph J. CullenRichard P. Wenzel2002 год

Intranasal Mupirocin to Prevent PostoperativeStaphylococcus aureusInfections
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Patients with nasal carriage of Staphylococcus aureus have an increased risk of surgical-site infections caused by that organism. Treatment with mupirocin ointment can reduce the rate of nasal carriage and may prevent postoperative S. aureus infections.We conducted a randomized, double-blind, placebo-controlled trial to determine whether intranasal treatment with mupirocin reduces the rate of S. aureus infections at surgical sites and prevents other nosocomial infections.Of 4030 enrolled patients who underwent general, gynecologic, neurologic, or cardiothoracic surgery, 3864 were included in the intention-to-treat analysis. Overall, 2.3 percent of mupirocin recipients and 2.4 percent of placebo recipients had S. aureus infections at surgical sites. Of the 891 patients (23.1 percent of the 3864 who completed the study) who had S. aureus in their anterior nares, 444 received mupirocin and 447 received placebo. Among the patients with nasal carriage of S. aureus, 4.0 percent of those who received mupirocin had nosocomial S. aureus infections, as compared with 7.7 percent of those who received placebo (odds ratio for infection, 0.49; 95 percent confidence interval, 0.25 to 0.92; P=0.02).Prophylactic intranasal application of mupirocin did not significantly reduce the rate of S. aureus surgical-site infections overall, but it did significantly decrease the rate of all nosocomial S. aureus infections among the patients who were S. aureus carriers.
Год издания: 2002
Авторы: Trish M. Perl, Joseph J. Cullen, Richard P. Wenzel, M. Bridget Zimmerman, Michael A. Pfaller, Deborah Sheppard, Jennifer Twombley, Pamela French, Loreen A. Herwaldt
Издательство: Massachusetts Medical Society
Источник: New England Journal of Medicine
Ключевые слова: Antimicrobial Resistance in Staphylococcus, Sinusitis and nasal conditions, Otolaryngology and Infectious Diseases
Другие ссылки: New England Journal of Medicine (PDF)
New England Journal of Medicine (HTML)
PubMed (HTML)