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Alterations inneurochemistry duringretinal degeneration Erica L. Fletcher2000 год

Alterations in neurochemistry during retinal degeneration
review

Страница публикацииПубликация в OpenAlex
Аннотация: Retinitis pigmentosa refers to a family of hereditary retinal degenerations that lead to photoreceptor death and vision loss. The underlying cause(s) are not known. In recent years there has been accumulating evidence of neurochemical changes during degeneration. In particular, the amino acids glutamate, GABA, and glycine show alterations in labelling intensity in subsets of neurons. Furthermore, there are differences in the labelling of the precursors, glutamine and aspartate, prior to, during, and following loss of photoreceptors, suggesting that the metabolic pathways involved in neurotransmitter formation and degradation may be abnormal. In addition, there is an elevation in glutamine and arginine content within Müller cells prior to the onset of photoreceptor death. Investigations evaluating Müller cell function indicate that formation and degradation of glutamate, in particular, is abnormal in the degenerating retina from an early age. These studies suggest that even though the primary genetic defect of the RCS rat is within the retinal pigment epithelium, Müller cells develop abnormally, and may contribute to the observed photoreceptor loss. Microsc. Res. Tech. 50:89–102, 2000. © 2000 Wiley-Liss, Inc.
Год издания: 2000
Авторы: Erica L. Fletcher
Издательство: Wiley
Источник: Microscopy Research and Technique
Ключевые слова: Retinal Development and Disorders, Neuroscience and Neuropharmacology Research, Retinal Diseases and Treatments
Другие ссылки: Microscopy Research and Technique (HTML)
PubMed (HTML)