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Neurophysiologicalcorrelates ofage-related changesin human motorfunction Venkata S. MattayFrancesco Saverio FeraAlessandro Tessitore2002 год

Neurophysiological correlates of age-related changes in human motor function
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Аннотация: Background: There are well-defined and characteristic age-related deficits in motor abilities that may reflect structural and chemical changes in the aging brain. Objective: To delineate age-related changes in the physiology of brain systems subserving simple motor behavior. Methods: Ten strongly right-handed young (<35 years of age) and 12 strongly right-handed elderly (>50 years of age) subjects with no evidence of cognitive or motor deficits participated in the study. Whole-brain functional imaging was performed on a 1.5-T MRI scanner using a spiral pulse sequence while the subjects performed a visually paced “button-press” motor task with their dominant right hand alternating with a rest state. Results: Although the groups did not differ in accuracy, there was an increase in reaction time in the elderly subjects (mean score ± SD, young subjects = 547 ± 97 ms, elderly subjects = 794 ± 280 ms, p < 0.03). There was a greater extent of activation in the contralateral sensorimotor cortex, lateral premotor area, supplementary motor area, and ipsilateral cerebellum in the elderly subjects relative to the young subjects (p < 0.001). Additional areas of activation, absent in the young subjects, were seen in the ipsilateral sensorimotor cortex, putamen (left > right), and contralateral cerebellum of the elderly subjects. Conclusions: The results of this study show that elderly subjects recruit additional cortical and subcortical areas even for the performance of a simple motor task. These changes may represent compensatory mechanisms invoked by the aging brain, such as reorganization and redistribution of functional networks to compensate for age-related structural and neurochemical changes.
Год издания: 2002
Авторы: Venkata S. Mattay, Francesco Saverio Fera, Alessandro Tessitore, Ahmad R. Hariri, Siba R. Das, Joseph H. Callicott, D.R. Weinberger
Издательство: Lippincott Williams & Wilkins
Источник: Neurology
Ключевые слова: Transcranial Magnetic Stimulation Studies, Advanced Neuroimaging Techniques and Applications, Functional Brain Connectivity Studies
Другие ссылки: Neurology (HTML)
PubMed (HTML)