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The Alzheimer'sDisease NeuroimagingInitiative: Progressreport and futureplans Michael W. WeinerPaul AisenClifford R. Jack2010 год

The Alzheimer's Disease Neuroimaging Initiative: Progress report and future plans
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Аннотация: The Alzheimer's Disease Neuroimaging Initiative (ADNI) beginning in October 2004, is a 6‐year research project that studies changes of cognition, function, brain structure and function, and biomarkers in elderly controls, subjects with mild cognitive impairment, and subjects with Alzheimer's disease (AD). A major goal is to determine and validate MRI, PET images, and cerebrospinal fluid (CSF)/blood biomarkers as predictors and outcomes for use in clinical trials of AD treatments. Structural MRI, FDG PET, C‐11 Pittsburgh compound B (PIB) PET, CSF measurements of amyloid β (Aβ) and species of tau, with clinical/cognitive measurements were performed on elderly controls, subjects with mild cognitive impairment, and subjects with AD. Structural MRI shows high rates of brain atrophy, and has high statistical power for determining treatment effects. FDG PET, C‐11 Pittsburgh compound B PET, and CSF measurements of Aβ and tau were significant predictors of cognitive decline and brain atrophy. All data are available at UCLA/LONI/ADNI, without embargo. ADNI‐like projects started in Australia, Europe, Japan, and Korea. ADNI provides significant new information concerning the progression of AD.
Год издания: 2010
Авторы: Michael W. Weiner, Paul Aisen, Clifford R. Jack, William J. Jagust, John Q. Trojanowski, Leslie M. Shaw, Andrew J. Saykin, John C. Morris, Nigel J. Cairns, Laurel Beckett, Arthur W. Toga, Robert C. Green, Sarah Walter, Holly Soares, Peter J. Snyder, Eric Siemers, William Z. Potter, Patricia E. Cole, Mark E. Schmidt
Издательство: Wiley
Источник: Alzheimer s & Dementia
Ключевые слова: Dementia and Cognitive Impairment Research, Alzheimer's disease research and treatments, Advanced Neuroimaging Techniques and Applications
Другие ссылки: Alzheimer s & Dementia (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)