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Studies on theperformance of theconductingpolymer‐basedmolecular releasesystem Saptarshi MajumdarKajari KarguptaSaibal Ganguly2011 год

Studies on the performance of the conducting polymer‐based molecular release system
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Аннотация: Abstract ‘Conducting polymeric (CP) membrane based controlled molecular release under applied electrical potential’ is an important futuristic application in ‘drug delivery’. A validated Poisson‐Nernst‐Planck based framework has been used in this study for the purpose of performance mapping for such a system. Leaking of the molecules during loading time and retention of molecules at the end of each voltage cycle have been identified here as the major bottlenecks in the use of this system in a sustainable basis. Peak flux of ionic molecules delivered is a key objective to be maximized along with minimum retention and leakage. Results reveal that parameters like time of voltage span, effective diffusivity, polymer film thickness need to be tightly maintained. At the same time, a wide variety of CP‐drug combinations can be acceptable. This opens the possibilities of utilizing this system for large range of therapeutic applications for controlled drug delivery. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers
Год издания: 2011
Авторы: Saptarshi Majumdar, Kajari Kargupta, Saibal Ganguly, Partha S. Ray
Издательство: Wiley
Источник: Polymer Engineering and Science
Ключевые слова: Conducting polymers and applications, Analytical Chemistry and Sensors, Advanced Sensor and Energy Harvesting Materials