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DrosophilaPax-6/eyeless isessential for normaladult brain structureand function Patrick CallaertsSining LengJason Clements2001 год

Drosophila Pax-6/eyeless is essential for normal adult brain structure and function
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Аннотация: A role for the Pax-6 homologue eyeless in adult Drosophila brain development and function is described. eyeless expression is detected in neurons, but not glial cells, of the mushroom bodies, the medullar cortex, the lateral horn, and the pars intercerebralis. Furthermore, severe defects in adult brain structures essential for vision, olfaction, and for the coordination of locomotion are provoked by two newly isolated mutations of Pax-6/eyeless that result in truncated proteins. Consistent with the morphological lesions, we observe defective walking behavior for these eyeless mutants. The implications of these data for understanding postembryonic brain development and function in Drosophila are discussed. © 2001 John Wiley & Sons, Inc. J Neurobiol 46: 73–88, 2001
Год издания: 2001
Авторы: Patrick Callaerts, Sining Leng, Jason Clements, Corinne Benassayag, David L. Cribbs, YY Kang, Uwe Walldorf, K.-F. Fischbach, Roland Strauß
Издательство: Wiley
Источник: Journal of Neurobiology
Ключевые слова: Neurobiology and Insect Physiology Research, Developmental Biology and Gene Regulation, Retinal Development and Disorders
Другие ссылки: Journal of Neurobiology (HTML)
PubMed (HTML)