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Biological Variationof Total, Free andPercent Free SerumProstate SpecificAntigen Levels inScreening Volunteers David K. OrnsteinDeborah S. SmithGanesh Rao1997 год

Biological Variation of Total, Free and Percent Free Serum Prostate Specific Antigen Levels in Screening Volunteers
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Аннотация: No AccessJournal of UrologyClinical Urology: Original Article1 Jun 1997Biological Variation of Total, Free and Percent Free Serum Prostate Specific Antigen Levels in Screening Volunteers David K. Ornstein, Deborah S. Smith, Ganesh S. Rao, Joseph W. Basler, Timothy L. Ratliff, and William J. Catalona David K. OrnsteinDavid K. Ornstein More articles by this author , Deborah S. SmithDeborah S. Smith More articles by this author , Ganesh S. RaoGanesh S. Rao More articles by this author , Joseph W. BaslerJoseph W. Basler More articles by this author , Timothy L. RatliffTimothy L. Ratliff More articles by this author , and William J. CatalonaWilliam J. Catalona More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64708-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined the biological variation of the total, free and percent free serum prostate specific antigen (PSA) in men 50 years old or older. Materials and Methods: Between July 1995 and February 1996 we studied 84 healthy men from our PSA screening study to determine biological variation by calculating the coefficients of variation of 3 PSA measurements on blood samples drawn from each subject 2 weeks apart. Results: The mean coefficients of variation for total, free and percent free serum PSA were 15, 17 and 14%, respectively. Age, total PSA and ejaculation were not confounding factors in this analysis (that is multivariate R2 less than 5% for all indexes). Conclusions: There is a mean variation of approximately 15% in measurements of total, free and percent free PSA that does not appear to be significantly affected by age and total PSA level. References 1 : Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. New Engl. J. Med.1991; 324: 1156. Google Scholar 2 : The clinical usefulness of prostate specific antigen: update 1994. J. Urol.1994; 152: 1358. Link, Google Scholar 3 : Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J. Urol.1994; 151: 1283. Abstract, Google Scholar 4 : Analytical performance goals for measuring prostate-specific antigen. Clin. Che.1993; 39: 1525. Google Scholar 5 : Effects of rectal examination, prostatic massage, ultrasonography and needle biopsy on serum prostate specific antigen levels. J. Urol.1992; 147: 810. 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Google Scholar From the Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byAnkerst D, Gelfond J, Goros M, Herrera J, Strobl A, Thompson I, Hernandez J and Leach R (2018) Serial Percent Free Prostate Specific Antigen in Combination with Prostate Specific Antigen for Population Based Early Detection of Prostate CancerJournal of Urology, VOL. 196, NO. 2, (355-360), Online publication date: 1-Aug-2016.Eggener S and Raman J (2018) Re: Effectiveness of Antibiotics Given to Asymptomatic Men for an Increased Prostate Specific AntigenJournal of Urology, VOL. 182, NO. 1, (396-397), Online publication date: 1-Jul-2009.Marks L, Andriole G, Fitzpatrick J, Schulman C and Roehrborn C (2018) The Interpretation of Serum Prostate Specific Antigen in Men Receiving 5α-Reductase Inhibitors: A Review and Clinical RecommendationsJournal of Urology, VOL. 176, NO. 3, (868-874), Online publication date: 1-Sep-2006.Daskivich T, Regan M and Oh W (2018) Prostate Specific Antigen Doubling Time Calculation: Not as Easy as 1, 2, 4Journal of Urology, VOL. 176, NO. 5, (1927-1937), Online publication date: 1-Nov-2006. Volume 157Issue 6June 1997Page: 2179-2182 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information David K. Ornstein More articles by this author Deborah S. Smith More articles by this author Ganesh S. Rao More articles by this author Joseph W. Basler More articles by this author Timothy L. Ratliff More articles by this author William J. Catalona More articles by this author Expand All Advertisement PDF downloadLoading ...
Год издания: 1997
Авторы: David K. Ornstein, Deborah S. Smith, Ganesh Rao, Joseph W. Basler, Timothy L. Ratliff, William J. Catàlona
Издательство: Lippincott Williams & Wilkins
Источник: The Journal of Urology
Ключевые слова: Prostate Cancer Diagnosis and Treatment, Prostate Cancer Treatment and Research, Urologic and reproductive health conditions
Другие ссылки: The Journal of Urology (HTML)
PubMed (HTML)