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Media criticism ofdoctors: review of UKjunior doctors'concerns raised insurveys M J Goldacre2003 год

Media criticism of doctors: review of UK junior doctors' concerns raised in surveys
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Аннотация: he had a few convulsions but no impaired consciousness or other signs of severe malaria.On day 2 the parasitaemia was 4%.Treatment was changed to mefloquine, which was successful.His 4 year old brother, case 2, was febrile with 0.5% infected erythrocytes.His symptoms resolved with atovaquone and proguanil hydrochloride, and the parasites were cleared after three days.On day 28 he was again febrile with P falciparum parasites and was successfully treated with mefloquine.The mother (case 3), although asymptomatic, had a few P falciparum rings.She was treated with atovaquone and proguanil hydrochloride, which cleared the parasites without recrudescence.Drug concentrations were measured by high pressure liquid chromatography in repeated serum samples.The concentrations of atovaquone (7.6-13.9M), proguanil (300-1200 nM), and cycloguanil (125-400 nM) were all above the levels considered therapeutic in children and adults. 3 Treatment failure could therefore not be attributed to poor bioavailability of the drug.Cases 1 and 3 were infected with single clones whereas case 2 had five genetically diverse parasite populations, detected by analysis of merozoite surface proteins 1 and 2. Mutation A803G (changing tyrosine to serine in 268) in cytochrome b, related to resistance to atovaquone, was detected in cases 2 and 3 by polymerase chain reaction and restriction fragment length polymorphism of loci 133, 268, 272, 275, 280, and 284, and confirmed by sequencing (table). 4However, only wild types were found in case 1. Analyses of loci 51, 59, 108, and 164 in the dihydrofolate reductase gene, related to resistance to proguanil and cycloguanil, revealed wild types in all samples except those from case 2, in which triple mutation were found at recrudescence.
Год издания: 2003
Авторы: M J Goldacre
Издательство: BMJ
Источник: BMJ
Ключевые слова: Diversity and Career in Medicine, Dental Education, Practice, Research, Medical Education and Admissions
Другие ссылки: BMJ (PDF)
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Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
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