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Mucosal immunityagainst parasiticgastrointestinalnematodes Denis Nnabuike OnahYukifumi Nawa2000 год

Mucosal immunity against parasitic gastrointestinal nematodes
review

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Аннотация: The last two decades witnessed significant advances in the efforts of immunoparasitologists to elucidate the nature and role of the host mucosal defence mechanisms against intestinal nematode parasites. Aided by recent advances in basic immunology and biotechnology with the concomitant development of well defined laboratory models of infection, immunoparasitologists have more precisely analyzed and defined the different immune effector mechanisms during the infection; resulting in great improvement in our current knowledge and understanding of protective immunity against gastrointestinal (GI) nematode parasites. Much of this current understanding comes from experimental studies in laboratory rodents, which have been used as models of livestock and human GI nematode infections. These rodent studies, which have concentrated on Heligmosomoides polygyrus, Nippostrongylus brasiliensis, Strongyloides ratti/S. venezuelensis, Trichinella spiralis and Trichuris muris infections in mice and rats, have helped in defining the types of T cell responses that regulate effector mechanisms and the effector mechanisms responsible for worm expulsion. In addition, these studies bear indications that traditionally accepted mechanisms of resistance such as eosinophilia and IgE responses may not play as important roles in protection as were previously conceived. In this review, we shall, from these rodent studies, attempt an overview of the mucosal and other effector responses against intestinal nematode parasites beginning with the indices of immune protection as a model of the protective immune responses that may occur in animals and man. Key words: mucosal immunity, intestinal nematodes, antibody, cytokines, eosinophils, mast cells, goblet cells
Год издания: 2000
Авторы: Denis Nnabuike Onah, Yukifumi Nawa
Издательство: Korean Society for Parasitology
Источник: Korean Journal of Parasitology
Ключевые слова: Parasites and Host Interactions, Helminth infection and control, Parasite Biology and Host Interactions
Другие ссылки: Korean Journal of Parasitology (HTML)
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