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Role of NPY and itsreceptor subtypes inforaging, foodhoarding, and foodintake by Siberianhamsters Diane E. DayErin Keen‐RhinehartTimothy J. Bartness2005 год

Role of NPY and its receptor subtypes in foraging, food hoarding, and food intake by Siberian hamsters
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Аннотация: Fasting has widespread physiological and behavioral effects such as increases in arcuate nucleus neuropeptide Y (NPY) gene expression in rodents, including Siberian hamsters. Fasting also stimulates foraging and food hoarding (appetitive ingestive behaviors) by Siberian hamsters but does relatively little to change food intake (consummatory ingestive behavior). Therefore, we tested the effects of third ventricular NPY Y1 ([Pro 34 ]NPY) or Y5 ([d-Trp 34 ]NPY) receptor agonists on these ingestive behaviors using a wheel running-based food delivery system coupled with simulated burrow housing. Siberian hamsters had 1) no running wheel access and free food, 2) running wheel access and free food, or 3) foraging requirements (10 or 50 revolutions/pellet). NPY (1.76 nmol) stimulated food intake only during the first 4 h postinjection (∼200–1,000%) and mostly in hamsters with a foraging requirement. The Y1 receptor agonist markedly increased food hoarding (250–1,000%), increased foraging as well as wheel running per se, and had relatively little effect on food intake (<250%). Unlike NPY, the Y5 agonist significantly increased food intake, especially in foraging animals (∼225–800%), marginally increased food hoarding (250–500%), and stimulated foraging and wheel running 4–24 h postinjection, with the distribution of earned pellets favoring eating versus hoarding across time. Across treatments, food hoarding predominated early postinjection, whereas food intake tended to do so later. Collectively, NPY stimulated both appetitive and consummatory ingestive behaviors in Siberian hamsters involving Y1/Y5 receptors, with food hoarding and foraging/wheel running (appetitive) more involved with Y1 receptors and food intake (consummatory) with Y5 receptors.
Год издания: 2005
Авторы: Diane E. Day, Erin Keen‐Rhinehart, Timothy J. Bartness
Издательство: American Physiological Society
Источник: AJP Regulatory Integrative and Comparative Physiology
Ключевые слова: Regulation of Appetite and Obesity, Neuropeptides and Animal Physiology, Receptor Mechanisms and Signaling
Другие ссылки: AJP Regulatory Integrative and Comparative Physiology (HTML)
PubMed (HTML)