1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Cognitive Impairmentin Pain throughAmygdala-DrivenPrefrontal CorticalDeactivation Guangchen JiHao SunYu Fu2010 год

Cognitive Impairment in Pain through Amygdala-Driven Prefrontal Cortical Deactivation
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Cognitive deficits such as impaired decision-making can be a consequence of persistent pain. Normal functions of the intact amygdala and prefrontal cortex are required for emotion-based decision-making that relies on the ability to assess risk, attribute value, and identify advantageous strategies. We tested the hypothesis that pain-related cognitive deficits result from amygdala-driven impairment of medial prefrontal cortical (mPFC) function. To do this, we used electrophysiological single-unit recordings in vivo , patch clamp in brain slices, and various behavioral assays to show that increased neuronal activity in the amygdala in an animal model of arthritis pain was accompanied by decreased mPFC activation and impaired decision-making. Furthermore, pharmacologic inhibition (with a corticotropin-releasing factor 1 receptor antagonist) of pain-related hyperactivity in the basolateral amygdala (BLA), but not central amygdala (CeA), reversed deactivation of mPFC pyramidal cells and improved decision-making deficits. Pain-related cortical deactivation resulted from a shift of balance between inhibitory and excitatory synaptic transmission. Direct excitatory transmission to mPFC pyramidal cells did not change in the pain model, whereas polysynaptic inhibitory transmission increased. GABAergic transmission was reduced by non-NMDA receptor antagonists, suggesting that synaptic inhibition was glutamate driven. The results are consistent with a model of BLA-driven feedforward inhibition of mPFC neurons. In contrast to the differential effects of BLA versus CeA hyperactivity on cortical-cognitive functions, both amygdala nuclei modulate emotional-affective pain behavior. Thus, this study shows that the amygdala contributes not only to emotional-affective but also cognitive effects of pain. The novel amygdalo-cortical pain mechanism has important implications for our understanding of amygdala functions and amygdalo-cortical interactions.
Год издания: 2010
Авторы: Guangchen Ji, Hao Sun, Yu Fu, Zhen Li, Miguel Pais-Vieira, Vasco Galhardo, Volker Neugebauer
Издательство: Society for Neuroscience
Источник: Journal of Neuroscience
Ключевые слова: Memory and Neural Mechanisms, Stress Responses and Cortisol, Pain Mechanisms and Treatments
Другие ссылки: Journal of Neuroscience (PDF)
Journal of Neuroscience (HTML)
PubMed Central (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed (HTML)