1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Asymmetrical lateralventricularenlargement inParkinson’s disease M. M. LewisAnna SmithMartin Styner2009 год

Asymmetrical lateral ventricular enlargement in Parkinson’s disease
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson's disease (PD). The current study explored these associations further.Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy control subjects at baseline and 12-43 months later. Baseline and longitudinal lateral ventricular volumetric changes were compared between contralateral and ipsilateral ventricles in PD subjects relative to symptom onset side and in controls relative to their dominant hand. Correlations between changes in ventricular volume and United Parkinson's disease rating scale motor scores (UPDRS-III) whilst on medication were determined.The lateral ventricle contralateral to symptom onset side displayed a faster rate of enlargement compared to the ipsilateral (P = 0.004) in PD subjects, with no such asymmetry detected (P = 0.312) in controls. There was a positive correlation between ventricular enlargement and worsening motor function assessed by UPDRS-III scores (r = 0.96, P < 0.001).There is asymmetrical lateral ventricular enlargement that is associated with PD motor asymmetry and progression. Further studies are warranted to investigate the underlying mechanism(s), as well as the potential of using volumetric measurements as a marker for PD progression.
Год издания: 2009
Авторы: M. M. Lewis, Anna Smith, Martin Styner, Hongbin Gu, Richard J. Poole, Hongtu Zhu, Yingying Li, X. Barbero, S. Gouttard, Martin J. McKeown, Richard B. Mailman, Xuemei Huang
Издательство: Wiley
Источник: European Journal of Neurology
Ключевые слова: Neurological disorders and treatments, Genetic Neurodegenerative Diseases, Parkinson's Disease Mechanisms and Treatments
Другие ссылки: European Journal of Neurology (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (PDF)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (HTML)
PubMed (HTML)