Genetics of Cognition: Outline of a Collaborative Twin Studyстатья из журнала
Аннотация: Abstract Amultidisciplinary collaborative study examining cognition in a large sample of twins is outlined. A common experimental protocol and design is used in The Netherlands, Australia and Japan to measure cognitive ability using traditional IQ measures (i.e., psychometric IQ), processing speed (e.g., reaction time [RT] and inspection time [IT]), and working memory (e.g., spatial span, delayed response [DR] performance). The main aim is to investigate the genetic covariation among these cognitive phenotypes in order to use the correlated biological markers in future linkage and association analyses to detect quantitativetrait loci (QTLs). We outline the study and methodology, and report results from our preliminary analyses that examines the heritability of processing speed and working memory indices, and their phenotypic correlation with IQ. Heritability of Full Scale IQ was 87% in the Netherlands, 83% in Australia, and 71% in Japan. Heritability estimates for processing speed and working memory indices ranged from 33–64%. Associations of IQ with RT and IT (−0.28 to −0.36) replicated previous findings with those of higher cognitive ability showing faster speed of processing. Similarly, significant correlations were indicated between IQ and the spatial span working memory task (storage [0.31], executive processing [0.37]) and the DR working memory task (0.25), with those of higher cognitive ability showing better memory performance. These analyses establish the heritability of the processing speed and working memory measures to be used in our collaborative twin study of cognition, and support the findings that individual differences in processing speed and working memory may underlie individual differences in psychometric IQ.
Год издания: 2001
Авторы: Margaret J. Wright, Eco J. C. de Geus, Juko Ando, Michelle Luciano, Daniëlle Posthuma, Yutaka Ono, Narelle K. Hansell, Caroline van Baal, Kai Hiraishi, Toshikazu Hasegawa, Glen A. Smith, Gina Geffen, Laurie Geffen, Shigenobu Kanba, Akira Miyake, Nick Martin, Dorret I. Boomsma
Издательство: Cambridge University Press
Источник: Twin Research
Ключевые слова: Cognitive Abilities and Testing, Genetic Associations and Epidemiology, Genetics and Neurodevelopmental Disorders
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Twin Research (HTML)
Data Archiving and Networked Services (DANS) (PDF)
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research.vu.nl (HTML)
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Том: 4
Выпуск: 1
Страницы: 48–56